2374. Ciprofloxacin.

1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid; Bay q 3939. C17H18FN3O3; mol wt

331.35. C 61.62%, H 5.48%, F 5.73%, N 12.68%, O 14.49%. Fluorinated quinolone antibacterial. Prepn: K. Grohe et

al., Ger. pat. 3,142,854; eidem, U.S. pat. 4,670,444 (1983, 1987 both to Bayer AG); K. Grohe, H. Heitzer, Ann. 1987, 29.

Antibacterial spectrum in vitro: B. Watt, F. V. Brown, J. Antimicrob. Chemother. 17, 605 (1986); C. M. Bassey et al., ibid.

623. HPLC determn in biological fluids: W. Gau et al., J. Liq. Chromatog. 8, 485 (1985). Pharmacokinetics: G. Hoffken et

al., Antimicrob. Ag. Chemother. 27, 375 (1985). Clinical trials: C. A. Ramirez et al., ibid. 28, 128 (1985); B. E. Scully et al.,

Lancet 1, 819 (1986). Symposia on antibacterial spectrum and clinical use: Am. J. Med. 82, Suppl. 4A, 1-404 (1987); J.

Antimicrob. Chemother. 26, Suppl. F, 3-193 (1990). Review of clinical safety and efficacy in children: R. Kubin, Infection 21,

413-421 (1993).

Dec 255-257 deg.

Monohydrochloride monohydrate, C17H18FN3O3.HCl.H2O, Bay o 9867, Baycip (Bayer), Ciflox (Bayer), Ciloxan (Alcon),

Ciprinol (Krka), Cipro (Bayer), Ciprobay (Bayer), Ciproxan (Bayer), Ciproxin (Bayer), Flociprin (IBI), Septicide (Bago),

Velmonit (Esteve). Light yellow crystalline powder. mp 318-320 deg.

THERAP CAT: Antibacterial.

2330. Cifenline.

2-(2,2-Diphenylcyclopropyl)-4,5-dihydro-1H-imidazole

Crystals from petr ether, mp 103-104 deg.

Cipralan (Roche),

THERAP CAT: Antiarrhythmic.

2377. Cisapride.

cis-4-Amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide;cis-4-amino-5-

chloro-N-[1-[3-(p-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-o-anisamide.

Cipril (Fisons),

Crystals from 2-propanol, mp 109.8 deg.

THERAP CAT: Peristaltic stimulant.

2379. Citalopram.

1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile; 1-[3-(dimethylamino)propyl]-1-(4-

fluorophenyl)-5-phthalancarbonitrile; nitalapram

bp0.03 175-181 deg.

Cipramil (Lundbeck). Crystals from isopropanol, mp 182-183 deg.

THERAP CAT: Antidepressant.

2373. Ciprofibrate.

2-[4-(2,2-Dichlorocyclopropyl)phenoxy]-2-methylpropanoic acid; 2-[4-(2,2-dichlorocyclopropyl)phenoxy]isobutyric acid

Pale cream solid from hexane, mp 114-116 deg.

THERAP CAT: Antihyperlipoproteinemic.

2842. Cyproheptadine (dichloride).